| UP | Used Part | |
| UP | United Press | |
| UP | University Press | |
|
| UP | University Place (Washington) | |
| UP | User Profile | |
| UP | User Program | |
| UP | Unit Price | |
| UP | University of Pennsylvania | |
| UP | University of Phoenix | |
| UP | Upgrade Package | |
| UP | Upper Division (degree plan) | |
| UP | Urban Planning | |
| UP | Ukraine | |
|
| UP | University of Portland | |
| UP | University of the Philippines | |
| UP | University of Pittsburgh | |
| UP | Utility Player | |
| UP | United Party (Papua New Guinea) | |
| UP | Union Pacific Corporation (US railroad) | |
| UP | United Planet | |
| UP | Upper Peninsula (of Michigan) | |
| UP | Universal Precautions (Centers for Disease Control) | |
| UP | Unified Process | |
| UP | University of Pretoria (South Africa) | |
| uP | Microprocessor | |
| UP | Unity Party | |
| UP | United Provinces (India) | |
| UP | Union Pacific Railroad Company | |
| UP | Universidade do Porto (University of Oporto, Portugal) | |
| UP | Unit Police (military) | |
| UP | Uttar Pradesh (state in India) | |
| UP | Unlimited Potential (various locations) | |
| UP | Uninterruptible Power | |
| UP | Unit Personnel | |
| UP | Universidad de Palermo (Spanish) | |
| UP | United Personnel | |
| UP | User Plane (Universal Mobile Telecommunications System) | |
| UP | Upwind | |
| UP | Universidad del Pacifico (Spanish: University of the Pacific, Peru) | |
| UP | Universidad Panamericana (Guadalajara, Mexico) | |
| UP | Under Provisions | |
| UP | Université de Poitiers (French: University of Poitiers; France) | |
| UP | Unsaturated Polyester | |
| UP | UniProcessor | |
| UP | Universiteit Van Pretoria (South Africa) | |
| UP | Unsolicited Proposal | |
| UP | Utgarde Pinnacle (World of Warcraft) | |
| UP | Unión Popular (Spanish: Popular Union) | |
| UP | Urban Pipeline (clothing) | |
| UP | Uillean Pipes | |
| UP | Utopia Planitia (Star Trek shipyard) | |
| UP | Urticaria Pigmentosa | |
| UP | User Priority | |
| UP | Ulcerative Proctitis | |
| UP | Uni-Processor | |
| UP | Union Parishad | |
| UP | Understanding Principles (Universal Foundation for Better Living) | |
| UP | Uniform Population (sectorization method) | |
| UP | Universität Passau (Germany) | |
| UP | Université de Perpignan | |
| UP | UniquePhones (website) | |
| UP | Union of Labor (Poland) | |
| UP | Utilities Privatization | |
| UP | Unknown Precipitation (METAR precipitation) | |
| UP | Unibersidad Ng Pilipinas (University of the Philippines) | |
| UP | Underproof | |
| UP | Umbral Plains (gaming, Everquest) | |
| UP | Union Pétrolière | |
| UP | Utopia Prime (gaming) | |
| UP | Uncrossable Parallel (Half-Life modification) | |
| UP | Unforgiven Promises (band) | |