The endocannabinoid N-arachidonoyl-dopamine (NADA) is able to both, increase the glutamatergic transmission to dopaminergic neurons by binding to the vanilloid receptor 1, and decrease it by binding to the CB1 receptor.
What does VR stand for?
VR stands for Vanilloid Receptor
This definition appears frequently and is found in the following Acronym Finder categories:
- Science, medicine, engineering, etc.
See other definitions of VR
We have 33 other meanings of VR in our Acronym Attic
- Transport Squadron (US Navy Aviation unit designation used from 1942 to 1958)
- Urbs Roma (Latin: City of Rome, epigraphy)
- V Rotate
- Vacation Rentals
- Vacation Resort
- Vacuum Residue
- Valid Reason
- Valtion Rautatiet (Railways of Finland)
- Valve-Regulated (battery)
- Vane Rate
Samples in periodicals archive:
Like capsaicin, the mechanism of action is thought to be through vanilloid receptor I antagonism.
These agents bind to the vanilloid receptor in the urothelium and/or afferent pathway and produce neural damage, leading to impairment of bladder function and even retention.
One area of growing interest relates to inflammation-related changes in ion channel expression, specifically the transient receptor potential ion channel, TRPV1 (formally known as vanilloid receptor 1).
Evodiamine has been shown to be a vanilloid receptor agonist which is responsible for thermoregulation.
University of California (Oakland, CA) has patented vanilloid receptor polypeptides and vanilloid receptor-related polypeptides, specifically the capsaicin receptor subtypes VR1 and VR2, as well as the encoding polynucleotide sequences.
The mechanism of action involves capsaicin-induced activation of vanilloid receptors located in epidermal and dermal sensory nerve fibers.