Levels of four serum markers - inhibin A, MSAFP, HCG, and unconjugated estriol (uE3) - were analyzed alone and in selected combinations for their association with stillbirth.
What does uE3 stand for?
uE3 stands for Unconjugated Estriol (abnormal pregnancy screening)
This definition appears frequently and is found in the following Acronym Finder categories:
- Science, medicine, engineering, etc.
See other definitions of uE3
- Urban Eye
- Urbaniste de l'Etat (French: Planner of the State)
- Usability Engineering
- Use of English
- User Equipment
- User Error
- User Experience
- United Engineers & Constructors, Inc.
- User Equipment Medium Access Control
- User Environment Virtualization (software)
- Unreal Engine 3 (gaming)
- Unattended Equipment Area
- Union Estonienne des Architectes (French: Estonian Union of Architects)
- Union Européenne de l'Ameublement (French: European Union of Furniture)
- United Earth Alliance
- Universal Esperanto Association (Netherlands)
- Universala Esperanto-Asocio (World Esperanto Association)
- University of East Anglia (UK)
- Upper Enclosure Assembly
- Urban Ecology Australia (est. 1991)
Samples in periodicals archive:
Studies have found that hCG testing alone can detect 40% of Down syndrome cases in the second trimester, while the addition of AFP and unconjugated estriol increases the sensitivity to 60%, and inhibin A further elevates the detection rate to 70%.
For example, microparticle enzyme immunoassay has errors in estradiol measurements due to interference from unconjugated estriol.
Screening for trisomy 18 has been in practice since the 1980s, when unconjugated estriol (uE3) and human chorionic gonadotropin (hCG) were added to the measurement of alphafetoprotein (AFP) as part of second trimester serum maternal screening protocols for Down syndrome.
Patients in the highest risk group (greater than 1:30 risk in this study) undergo CVS, those in the lowest risk group (less than 1:1,500 risk) receive no further testing, and those in the borderline risk group (between 1:30 and 1:1,500 risk) undergo quad screening (serum alpha feto-protein, hCG, unconjugated estriol, and inhibin A) in the second trimester and receive a final risk assessment based on all the measures, with a risk cutoff for further testing of 1:270, Dr.
The quadruple test calculates the risk of a Down syndrome term pregnancy based on the maternal age and concentration of four markers in maternal serum--alpha-fetoprotein, unconjugated estriol, human chorionic gonadotropin and inhibin-A--at weeks 14 to 22 of the pregnancy.
An analysis of the effect of analytical imprecision in the 2nd-trimester triple test [a-fetoprotein (AFP), human chorionic gonadotropin (hCG), and unconjugated estriol (uE3)] showed that individual patient risk figures can change dramatically owing to compounding effects of errors in each of the 3 component test measurements (8).