[1,2] The HIV treatment programme in Khayelitsha, Cape Town, which began using stavudine as a first-line therapy in 2003, reported approximately 10% of patients switching from stavudine to the alternative drug after 12 months due to hyperlactataemia.
What does d4T stand for?
d4T stands for Stavudine (aka Zerit; HIV treatment drug)
This definition appears very frequently and is found in the following Acronym Finder categories:
- Science, medicine, engineering, etc.
See other definitions of d4T
We have 3 other meanings of d4T in our Acronym Attic
- Drama for Learning and Creativity (UK)
- Developing for Learning Design (Joint Information Systems Committee; UK)
- Design for Mobile
- Democracy for Metro Detroit
- Design For People (design methodology)
- D4 Dopamine Receptor
- Design for Sustainability
- Dressed Four Sides (lumber; same as S4S)
- Didehydrodeoxythymidine (antiviral drug)
Samples in periodicals archive:
However, resource constraints limit the national programme to use nucleoside reverse transcriptase inhibitors (NRTIs) like zidovudine (AZT) or stavudine (d4T) with lamivudine (3TC) and non nucleoside reverse transcriptase inhibitors (NNRTI) like nevirapine and efavirenz for highly active anti-retroviral therapy (HAART).
In sweeping changes to its guidelines, the WHO said"that countries progressively phase out the use of stavudine as a preferred first-line therapy option and move to less toxic alternatives such as zidovudine (AZT) or tenofovir (TDF).
A triple combination of antiretrovirals lamivudine, stavudine and nevirapine will soon be available in the Cuban market, says Marlen Espino, director of state-funded pharmaceutical producer Novatec Laboratories.
For example, didanosine and stavudine concentrations drop to subtherapeutic levels when these drugs are taken with methadone.
Frank Maldarelli and colleagues from the National Institutes of Health (NIH) reported that interruption of stavudine (Zerit) in 3 patients who were receiving it as part of a failing regimen resulted in significant increases in viremia.
After the normalization of mitochondrial tests (defined by lactate/pyruvate ratio <30 and [beta]OH/AA ratio <2), an effective combination therapy (one antiprotease and two NRTIs, or three NRTIs excluding either stavudine or didanosine) was reintroduced several weeks to months later, and no lactic acidosis occurred (median follow-up, 6 months).