The authors used AhR agonists and small interfering RNA (siRNA) to examine the effect of AhR on PPAR-[alpha] expression and glycolysis in the Hepa-lclc7 (c7) liver cell line, and Bmall (brain, muscle ARNT-like protein 1) siRNA and Ahr or Bmall expression plasmids to analyze the effect of BMAL1 on PPAR-[alpha] expression in c7 cells.
What does siRNA stand for?
siRNA stands for Small Interfering RNA (duplexes)
This definition appears very frequently and is found in the following Acronym Finder categories:
- Science, medicine, engineering, etc.
- State Insurance and Risk Management Board (Connecticut)
- Senior Information Resources Management Official (US DoD)
- Stimulus-Induced Repetitive Muscle Potentials (neuroscience)
- Strategic Information Resource Management Planning
- Stable Isotope Ratio Mass Spectrometry
- Scottish Infection Research Network (UK)
- Security Incident Response Notification
- Social Insurance Research Network (Social Science Research Network)
- Solar Irradiance Research Network (US NASA)
- Stop It Right Now
- Scientific and Industrial Research Organization (India)
- Senior Information Risk Owner (UK)
- Service in Random Order (queuing theory)
- Simultaneous Intersecting Runway Operation (aviation; Transport Canada)
- Software Inspection and Review Organization (Sunnyvale, CA)
- Structure, Information, Communication, and Complexity (International Colloquium)
- Systeme d'Information de la Region de l'Ocean Indien
- Soroptimist International Region of Malaysia
- Solar and Infrared Radiation Observing System (hemispherical solar analysis)
- Staten Island Rapid Transit Operating Authority (now Staten Island Railroad)
Samples in periodicals archive:
The investigators described how they used small interfering RNA technology to silence the biochemical signals that attract a particular group of inflammatory cells to areas of tissue damage.
This intellectual property encompasses certain aspects of gene silencing in mammalian cells by small interfering RNA (siRNA) molecules, the natural mechanism that will be harnessed by RNAi therapeutics.
The molecule, known as a chimaera, is composed of two different types of RNA: a small interfering RNA (siRNA), designed to enter infected cells and block the expression of two genes that HIV needs to replicate, and an RNA sequence known as an aptamer, which binds tightly to gp120, a protein found on the surface of HIV and HIV-infected cells.
Some specific topics covered include chemical vectors for delivery of nucleic acid-based drugs, lipid nanoparticle-based systems for delivery of biomacromolecule therapeutics, nanocarriers for the delivery of peptides and proteins, pulmonary delivery of small interfering RNA for novel therapeutics, and influenza virosomes as delivery systems for antigens.