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What does 16MO stand for?

16MO stands for Sextodecimo (book paper size)

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Samples in periodicals archive:

Very careful examination of extant copies of the book allows Cohen to establish some new facts: for example, that while the book appears to be bound as octavo, its printing format is sextodecimo, and that Bridges' insistence on correcting some ill-reproduced photographs of Hopkins accounts for this book having two binding states.