| SPE | Society of Petroleum Engineers | |
| SPE | Solid Phase Extraction | |
| SPE | Strategic Planning and Evaluation (US FEMA) | |
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| SPE | Sony Pictures Entertainment | |
| SPE | Special Purpose Entity | |
| SPE | Synchronous Payload Envelope | |
| SPE | Siemens Professional Education (formerly Siemens-Berufsausbildung) | |
| SPE | Synergistic Processor Element | |
| SPE | Static Phase Error (US NASA) | |
| SPE | Sophisticated Paint Endorsement (American Institute of Steel Construction, Inc.) | |
| SPE | Skill Performance Evaluation (various organizations) | |
| SPE | Signal Processing Equipment | |
| SPE | Storage Processor Enclosure | |
|
| SPE | Synergistic Processing Element | |
| SPE | Service Provider Edition (software) | |
| SPE | Society of Professional Engineers | |
| SPE | Society for Photographic Education | |
| SPE | Sigma Phi Epsilon | |
| SPE | Svenska Petroleum Exploration (Sweden) | |
| SPE | Serum Protein Electrophoresis | |
| SPE | Submassive Pulmonary Embolism | |
| SPE | Sensitive Protective Equipment | |
| SPE | Solid Polymer Electrolyte | |
| SPE | Software Performance Engineering | |
| SPE | Senior Procurement Executive | |
| SPE | Single Point of Entry | |
| SPE | Streptococcal Pyrogenic Exotoxin | |
| SPE | Service Processing Element (Cisco) | |
| SPE | Subgame Perfect Equilibrium (game theory) | |
| SPE | Solar Particle Event | |
| SPE | Solid Phase Epitaxy | |
| SPE | Societas Privata Europaea (Latin: European Private Company) | |
| SPE | Society of Plastics Engineers, Inc. | |
| SPE | Software Product Engineering | |
| SPE | Solar Proton Event | |
| SPE | Servicios Públicos de Empleo (Spanish) | |
| SPE | Supervisory Patent Examiner | |
| SPE | Special Purpose Equipment | |
| SPE | Sales Per Employee | |
| SPE | Symbolic Programming Environment | |
| SPE | Semiconductor Production Equipment | |
| SPE | Solid Particle Erosion | |
| SPE | Société Coopérative de Production d'Electricité (Belgium electric company) | |
| SPE | Software Product Evaluation | |
| SPE | Solid Phase Epitaxial Regrowth | |
| SPE | Sony Pictures Employment | |
| SPE | SIPRnet Premise Equipment | |
| SPE | Secondary Particulate Emissions | |
| SPE | SONET Payload Envelope | |
| SPE | Sumiju Plant Engineering (Japan) | |
| SPE | Sauber Petronas Engineering | |
| SPE | Society for Pure English | |
| SPE | subtracting pore effect | |
| SPE | Synergistic Processing Engine | |
| SPE | Satellite Precipitation Estimate | |
| SPE | Soy Phytoestrogen | |
| SPE | Small Program Enhancement (IBM) | |
| SPE | Supplier Performance Evaluation (various companies) | |
| SPE | Spacecraft Power Electronics | |
| SPE | Sciences Physiques pour l'Enseignement (French: Physics for Education) | |
| SPE | Sensor Processing Electronics | |
| SPE | Services Protected Evacuation | |
| SPE | Spherical Probable Error | |
| SPE | Systems Performance Effectiveness | |
| SPE | Swedish Penis Enlarger (Austin Powers) | |
| SPE | Stored Program Element (USAF SACCS 465L EDTCC) | |
| SPE | Service Provisioning Environment | |
| SPE | Software Product Expert | |
| SPE | Startup Phase Error | |
| SPE | Sulfur Polymer Encapsulation | |
| SPE | Systems Planning & Engineering | |
| SPE | Sum of Predicted Error | |
| SPE | Single Piston Effect (valve engineering) | |
| SPE | Service Platform Engineering | |
| SPE | South Pit Extension (Project; Australia) | |
| SPE | Single Pair Ethernet | |