It is widely known that PIP3 can bind to the Pleckstrin homology domain (PH domain), which is the major factor involved in Ala activation (Hawkins et al.
What does PLEK stand for?
PLEK stands for Pleckstrin
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Samples in periodicals archive:
signal transduction processes (centaurin, delta 1; NCOA2; pleckstrin and Sec7 domain containing 3; protein phosphatase 2, regulatory subunit B [B56], [gamma] isoform), transcriptional regulation (NCOA2; POU domain, class 2, transcription factor 1; ETS variant gene 3), and cell proliferation pathways (hypothetical protein FLJ36090, epidermal growth factor receptor pathway substrate 15).
S1_at PLEKHG2 Pleckstrin homology domain containing, family G (with RhoGef domain) member 2 LRG1 Leucine-rich alpha-2 -glycoprotein 1 Bt.
[11] Human genes: GSTP1, glutathione-S-transferase pi; RARB, retinoic acid receptor [beta]; APC, adenomatous polyposis coli; ACTB, [beta]-actin; EDNRB, endothelin receptor type B; RASSF1, Ras association (RalGDS/AF-6) domain family member 1; CDKN2A, cyclin-dependent kinase inhibitor 2A (formerly p16); PSCD2, pleckstrin homology, Sec7 and coiled-coil domains 2 (formerly ARF); MGMT, O-6-methylguanine-DNA methyltransferase.
Abbreviations: AM, alveolar macrophages; PA, Pseudomonas aeruginosa; GST, glutathione S transferase; YFP, yellow fluorescent protein; GFP, green fluorescent protein; PH, pleckstrin homology domain, Lyn, v-yes yamaguchi sarcoma related gene / protein; PI3K, phosphoinositol -3- kinase; Akt, protein kinase B; MHS, murine alveolar macrophage cell line from ATCC.
Among the topics are inositol lipids and RTPC channel activation, pleckstrin homology domains and phospho-inositides, inositol polyphosphate kinases as regulators of nuclear function, and the evolution of the diverse biological roles of inositols.