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What does MGS2S stand for?

MGS2S stands for Metal Gear Solid 2: Substance (game)

This definition appears somewhat frequently and is found in the following Acronym Finder categories:

  • Slang/chat, popular culture

Samples in periodicals archive:

METAL GEAR SOLID 2: SUBSTANCE (X-Box, Konami) WHEN following up one of the best-selling computer games of all time, it's best to stick to a winning formula.