This has been most clearly demonstrated for several of the genes responsible for the syndrome designated maturity-onset diabetes of the young (MODY)  (13).
What does MODY stand for?
MODY stands for Maturity-Onset Diabetes of the Young
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Samples in periodicals archive:
8) Another example where the specific genetic variant determines clinical presentation and treatment response is maturity-onset diabetes of the young (MODY).
Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young.
Maturity-onset diabetes of the young (MODY), a subtype of non-insulin dependent diabetes mellitus, is an example.
To the Editor: Mutations in the glucokinase gene lead to an impaired sensing of blood glucose by the pancreatic [beta] cell, causing an autosomal dominant form of type 2 diabetes, maturity-onset diabetes of the young type 2 (MODY2).
They also identified genes responsible for myotonic dystrophy (141: 102), maturity-onset diabetes of the young (141: 300), two forms of the eye disorder macular degeneration (142: 37), and a gene that predisposes women to breast cancer following exposure to extremely low doses of radiation (141: 4).
Other research by his team suggests that identification of two phenotypes of maturity-onset diabetes of the young (MODY) can allow beneficial changes in treatment--even in patients who have had up to 30 years of suboptimal therapy.