We believe BMN-701 has the potential to possibly deliver more enzyme to lysosomes compared to traditional mannose-6-phosphate targeted approaches using the recently acquired GILT technology.
What does M6P stand for?
M6P stands for Mannose-6-Phosphate
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Samples in periodicals archive:
The type 2 IGF receptor, also known as cation-independent mannose-6-phosphate receptor (IGF-R2/ M-6-P), is structurally and functionally different from the IGF-R1.
GA is actively transported into human lysosomes via mannose-6-phosphate receptor-mediated endocytosis (5).
As Genzyme has presented at two scientific meetings, the Fabrazyme protein is fully sialylated, which reduces non-specific removal by the liver, and it has appropriate levels of mannose-6-phosphate to ensure uptake into the proper compartment (lysosomes) of the target cells.
Canfield, a recognized leader in the field of LSDs, is responsible for Novazyme's mannose-6-phosphate (M6P) technology that was developed at the University of Oklahoma.