What does MEF1 stand for?

Induction of CYP3A4 or MDR1 by vitamin E could potentially lower the efficacy of any drug metabolized by CYP3A4 or MDR1.

All of the current PIs are substrates for the P-glycoprotein efflux pump in the small intestine, and polymorphisms in the multidrug transporter MDR1 gene encoding P-glycoprotein may have significant implications for protease inhibitor exposure, efficacy and toxicity Polymorphisms in drug transporters with potential relevance to antiretroviral therapy include P-glycoprotein (PIs, zidovudine, nevirapine) and organic anion transporters (OATs) (tenofovir) Pharmacogenomics Defined It is widely recognized that all classes of antiretroviral agents have multiple effects other than suppression of HIV replication and are associated with many adverse effects, some of which can be life threatening].

As shown in Figure 6, BPA significantly induced the expression of mRNA encoding the PXR target genes CYP3A4, UGT1A1, and MDR1 in a dose-dependent manner compared with solvent controls.

More importantly, the direct evidence indicating that P-gp is responsible, in part, for acquisition of ATRA resistance in APL cells came from the experiment using ribozymes, which are able to target MDR1 RNA by a catalytic activity.

MDR1 encodes P-glycoprotein, a key protein involved in drug transport that is known to modulate drug disposition.

However, cells that had the atypical codon in combination with two other mutations in MDR1 pumped out some drugs with above-average effectiveness and others with below-average success.

P-glycoprotein, which is a membrane protein that functions as an exporter of xenobiotics from cells, is a product of the MDR1 gene.