| MC | Most Common | |
| MC | Mine Craft (game) | |
| MC | Macao | |
|
| MC | Monaco (ISO Country Identifier) | |
| MC | Monte Carlo | |
| MC | Mind Control (video game, World of Warcraft) | |
| MC | Mississippi College (Clinton, Mississippi) | |
| MC | Montgomery College | |
| MC | McCormick (spice company) | |
| MC | Motorcycle | |
| MC | Michigan City (Indiana) | |
| MC | Movie Clip | |
| MC | Middle Class | |
|
| MC | Marine Corps | |
| MC | Main Character (writing) | |
| MC | Mill Creek (Washington) | |
| MC | MasterCard | |
| MC | Multiple Choice | |
| MC | Motor Control (International Society of Motor Control journal) | |
| MC | Memory Card | |
| MC | Military Cross (British) | |
| MC | Measurement and Control | |
| MC | Master Chief (US Navy) | |
| MC | Mind Control | |
| MC | Merry Christmas | |
| MC | Mini Cooper (car) | |
| MC | Multi Channel | |
| MC | Mariah Carey (singer) | |
| MC | Moving Coil | |
| MC | Mayo Clinic | |
| MC | Methodist Church | |
| MC | Management Committee | |
| MC | Master Control | |
| MC | Midnight Commander (GNU software project) | |
| MC | Mint Condition | |
| MC | Motorcycle Club | |
| MC | Main Campus | |
| MC | Mad Cow | |
| MC | Committee Member (Boy Scouts of America) | |
| MC | Motor Car | |
| MC | Member of Congress | |
| MC | Mission Critical | |
| MC | Multi-Coated (camera lenses) | |
| MC | Moving Center | |
| MC | Marginal Cost | |
| MC | Manchester City | |
| MC | Management Consultant | |
| MC | Moisture Content | |
| MC | Morse Code | |
| MC | Marvel Comics | |
| MC | Move the Crowd | |
| MC | Measurement Canada | |
| MC | Master of Ceremonies | |
| MC | Market Capitalization | |
| MC | Medical Corps | |
| MC | Montgomery County Community College | |
| MC | Music Channel (websites) | |
| MC | Miley Cyrus (singer) | |
| MC | Motley Crue (band) | |
| MC | Magny-Cours (computing system) | |
| MC | Mitsubishi Corporation (Tokyo, Japan) | |
| MC | Message Center | |
| MC | Mother of Christ | |
| MC | Miranda Cosgrove (actress and musician) | |
| MC | Monmouth College (Illinois) | |
| MC | Maltese Cross | |
| MC | Mini Car | |
| MC | Memory Controller | |
| MC | Methylene Chloride (chemical) | |
| MC | Mast Cells | |
| MC | Metal Case (full metal jacket) | |
| MC | Manchester College (North Manchester, Indiana) | |
| MC | Menstrual Cycle | |
| MC | Master Cylinder (automotive) | |
| MC | Midland College (Midland, TX) | |
| MC | María Celeste (entertainer) | |
| MC | Microchip | |
| MC | medicine chest | |
| MC | Molten Core (gaming, World of Warcraft) | |
| MC | Mail Client | |
| MC | Master Clear | |
| MC | Michael Crawford (musician) | |
| MC | Michael Collins (Irish rebel) | |
| MC | Marin Catholic (school) | |
| MC | Medical Certificate | |
| MC | Mobile Computer (wireless networking; various companies) | |
| MC | Midnight Club | |
| MC | Motion Compensation | |
| MC | Mission Control | |
| MC | Margin Call (trading) | |
| MC | Magna Carta | |
| MC | Mini Comic | |
| MC | Major Component | |
| MC | Microcontroller | |
| MC | Management Control | |
| MC | Micro Cassette | |
| MC | Metal Clad | |
| MC | Maryville College (Tennessee) | |
| MC | Magnetic Contactor (electric circuits) | |
| MC | Mario Camposeco (Guatemalan soccer team) | |
| MC | MediaCorp | |
| MC | Maritime Commission (US Navy) | |
| MC | Macerata, Marche (Italian province) | |
| MC | Mad Catz (game accessory maker) | |
| MC | Makati City (Philippines) | |
| MC | Mini Clip (games and entertainment website) | |
| MC | Messiah College (Grantham, Pennsylvania) | |
| MC | Movement Control | |
| MC | Meningococcal | |
| MC | Mandaluyong City (Philippines) | |
| MC | Mutualité Chrétienne | |
| MC | Material Coordinator | |
| MC | Message Code | |
| MC | Marietta College (Marietta, Ohio, USA) | |
| MC | Markov Chain | |
| MC | Manual Control | |
| MC | Marshall Cavendish (international publisher) | |
| MC | Menstrual Cramps | |
| MC | Missile Command (gaming) | |
| MC | Multi-Cell | |
| MC | Medicare Choice | |
| MC | Master Clock | |
| MC | Mentally Challenged | |
| MC | Mission Capability | |
| MC | Memory Configuration (computer memory) | |
| MC | Malay College | |
| MC | Marketing Center | |
| MC | Memory Cell | |
| MC | Model Citizen (gaming) | |
| MC | Middlebury College (Middlebury, VT) | |
| MC | Makin' Cash | |
| MC | Manufacturing Cost | |
| MC | Micro Cell | |
| MC | Minish Cap (Legend of Zelda game) | |
| MC | Mercy Corps | |
| MC | Management Council | |
| MC | Methyl Cellulose | |
| MC | Maintenance Cost | |
| MC | Marikina City (Philippines) | |
| MC | Marriage Counselor | |
| MC | Macaroni Cheese | |
| MC | Mendeleev Communications | |
| MC | Multicarrier | |
| MC | Mission Complete | |
| MC | Missionary Church, Inc. (established 1969) | |
| MC | Muhlenberg College (Allentown, PA) | |
| MC | Marcus Camby (NBA player) | |
| MC | Mechanical Contractor | |
| MC | Management Code | |
| MC | Minister of Culture | |
| MC | Major Code (Maricopa County, AZ community college system) | |
| MC | Micro Channel | |
| MC | Monitoring Center | |
| MC | Microphone Checker | |
| MC | Market Committee | |
| MC | Millsaps College (Jackson, MS) | |
| MC | Missionaries of Charity (religious order) | |
| MC | Magistrates' Courts (UK) | |
| MC | Military Committee (NATO) | |
| MC | Mass Chromatography | |
| MC | Metrocard (MTA New York City Transit bus/subway fare card) | |
| MC | Military Capability | |
| MC | Mission Commander | |
| MC | Midcourse | |
| MC | Magnetic Course | |
| MC | Magnetic Core | |
| MC | Ministerial Conference | |
| MC | Maintenance Center | |
| MC | Marching Cubes (visualization algorithm) | |
| MC | Making Cash | |
| MC | Maurits Cornelis (Escher's initials) | |
| MC | Microelectronic Circuits | |
| MC | Missed Connection | |
| MC | Millennium Challenge (US Armed Forces joint field experiment) | |
| MC | Medium Coeli | |
| MC | Megacycle (now megahertz) | |
| MC | Mass Communication Specialist (US Navy) | |
| MC | Machine-Centered | |
| MC | Mobilization Center (US FEMA) | |
| MC | Maintenance Control | |
| MC | Maintenance Check | |
| MC | Multicurrency | |
| MC | Mystery Credit (blogging) | |
| MC | Methyl Chloroform | |
| MC | Microphone Controller | |
| MC | Mobile Crane | |
| MC | Mission Computer | |
| MC | Military Computer | |
| MC | Mennonite Conference | |
| MC | Multicast Capable | |
| MC | Momentary Contact | |
| MC | Main Controller | |
| MC | Military Air Post (Scott Catalogue prefix; philately) | |
| MC | Menninger Clinic (Houston, TX) | |
| MC | Mon Calamari (Star Wars starship prefix) | |
| MC | Manufacturing Control | |
| MC | Myotonia Congenita | |
| MC | Maritime Center | |
| MC | Multipoint Controller (Cisco) | |
| MC | MacDonald Cartier (trans-Canada Highway 401) | |