1,2) In addition to an association with low birth weight, there are several linked genetic diseases including overgrowth syndromes such as Beckwith-Wiedemann syndrome, chromosomally linked conditions (trisomies 2, 8 and 20) and X-linked Simpson-Golabi-Behmel syndrome, type 1 glycogen storage diseases, Li-Fraumeni syndrome, familial adenomatous polyposis (FAP) (3-6) and type 1 neurofibromatosis.
What does LFS stand for?
LFS stands for Li-Fraumeni Syndrome (cancer predisposition syndrome)
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We have 135 other meanings of LFS in our Acronym Attic
- Laser Fence Sensor
- Lateral Flow Strip
- Law Firm Services (various locations)
- Lead Free Slug (small caliber ammunition)
- Leadership, Friendship, Service (motto)
- League of Filipino Students
- Learning for Sustainability
- Legacy Financial System (US EPA)
- Legion of Fallen Souls (gaming clan)
- Lexus Financial Service (various locations)
- Libertarian Futurist Society (political foresight group)
- Licensed Financial Services Division
- Lifelong Friendship Society (Brooklyn, NY)
- Link Fault Signaling (protocol)
- Linux Filesystem Standard
- Linux from Scratch
- Lip Fullness Scale (dermatology)
- Live for Speed (computer racing simulation)
- Local File System
- Local Fish Store
Samples in periodicals archive:
TP53 Mutations in the TP53 gene on 17p are also known to predispose to early breast cancer  and account for over 70% of cases of Li-Fraumeni syndrome .
Mutations of CHEK2 may double the risk of breast cancer, and--although extremely rare--inherited mutations of TP53 in families with Li-Fraumeni syndrome, and PTEN in families with Cowden syndrome are tied to high risk of early-onset breast cancer.
The 1100delC mutation in exon 10 abolishes the kinase function of CHEK2 (5) and has been reported in patients with Li-Fraumeni syndrome in the United States and in Finnish families with a cancer phenotype suggestive of Li-Fraumeni syndrome, including breast cancer (5).
Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.