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This reaction involves the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine, producing tetrahydrofolate and methionine.
Association of parental hyperhomocysteinemia and C677T Methylene tetrahydrofolate reductase (MTHFR) polymorphism with recurrent pregnancy loss.
Folic acid in the body must be transformed into biologically active tetrahydrofolate acid in order to play a role.
Leucovorin provides a source of the tetrahydrofolates that are depleted by methotrexate's inhibition of dihydrofolate reductase, but methotrexate competes with leucovorin for cell uptake.
Thrombophilia investigation included determinations of protein C, protein S, antithrombin, and activated protein C resistance, factor V Leiden (FVL), prothrombin 20210A (PT 20210) and methylene tetrahydrofolate reductase (MTHFR) C677T mutations, antiphospholipid antibodies (APA), factor VIII levels, and homocysteine levels.
Prevalence of methylene tetrahydrofolate reductase polymorphism in South Indian population.
[FIGURE 1 OMITTED] [FIGURE 2 OMITTED] In an experiment by Idrees et al (44) NO donors decreased [14C] methyl tetrahydrofolate incorporation into protein; and homocysteine reduced the effectiveness of PAPA-NONOate (propylamine prompylamine NONOate) as an inhibitor of de novo purine nucleotide synthesis.
Rima Rozen & Philippe Goyette, "Methods for detecting methylene tetrahydrofolate reductase allelic variants" U.