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10) Differential Diagnosis Differential diagnoses for PBL include chronic osteomyelitis, primary bone sarcoma, leukemic infiltrate, small blue round cell tumors (including Ewing sarcoma/primitive neuroectodermal tumor, rhabdomyosarcoma, metastatic neuroblastoma, and small-cell osteosarcoma), metastatic sarcomas, mesenchymal chondrosarcoma, and metastatic carcinoma.
Histopathologic examination of both specimens identified a small round cell malignant neoplasm with a uniform, monotonous population of small blue round cells and effacement of normal architecture (figure 2).