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While previous studies showed that MPA induces receptor activator of nuclear factor kappa-B ligand (RANKL) expression in rodent mammary gland, MPA reduced levels of RANKL in human tumor xenografts.
Across multiple animal models of human tumor xenografts, treated animals experienced complete responses and remained tumor free up to 6 months post treatment.
Consistent with its mechanism of action, AEG40826 causes a rapid loss of IAP proteins in human tumor xenografts.
today announced presentation of positive pre-clinical data showing that Trubion's TRU-016 has potent anti-tumor activity and induces significant long-term tumor eradication in a human tumor xenograft model in which rituximab failed to induce durable responses.
MT * Establishing primary human tumor xenografts for use in oncology drug discovery * Lead investigator: Jill Donelan, Ph.
The human tumor xenografts were developed in ANAVEX labs using a sample taken from a person suffering from clear cell sarcoma.
Based on their interesting in vitro profiles, all three follow-up candidates will be subjected to human tumor xenograft in vivo models aimed at selecting an AEZS-112 follow-up candidate for preclinical development.
SAR566658 * "Preclinical evaluation of SAR566658 (huDS6-DM4) in mice bearing human tumor xenografts of breast, ovarian, lung, cervical and pancreatic cancer" (abstract #525); and * "In vivo stability in mice of SAR566658 (huDS6-DM4), an immunoconjugate targeting solid tumours (abstract #533).