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Diffusion tensor imaging produces a measurement, called fractional anisotropy (FA), of the movement of water molecules along axons.
The investigators compared generalized fractional anisotropy (GFA) values in 118 bipolar I patients recruited from multiple university-affiliated centers in France, Germany, and the United States, with a control group of 86 participants who had no personal or family history of Axis I mood disorders, schizophrenia, or schizoaffective disorder.
They found that, from childhood into early adulthood, differences in fractional anisotropy -- a measure of connectivity -- of the cingulum were associated with executive functioning, whereas fractional anisotropy of the inferior fronto-occipital fasciculus was associated with visual learning and global cognitive performance via speed of processing.
Fractional anisotropy (FA) indicates how directionalthediffusion is in a particular voxel.
fractional anisotropy (FA) and mean diffusivity (MD).
Fractional anisotropy (FA) is a measure derived from the diffusion tensor imaging that assesses the degree of anisotropic self-diffusion, i.
These commonly include fractional anisotropy (FA) and mean diffusivity (MD).
With DW-MRI, lower apparent diffusion coefficient (ADC) values in gray matter and higher fractional anisotropy (FA) values in white matter, compared with controls, are thought to reflect preservation of brain integrity.