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The ER also contains calcium-binding buffering proteins, calreticulin and calsequestrin and others having low affinity for the calcium ion, adding to the fine control over calcium concentrations.
The interaction of classical complement component Cl with parasite and host calreticulin mediates Trypanosoma cruzi infection of human placenta.
Calreticulin (spot 3) is a major endoplasmic reticulum [Ca.
This complex of B2 microglobulin, calreticulin, ERp57, TAP, tapasin and MHC Class I functions to hold MHC molecules until they have been fully loaded with peptides.
This research demonstrates that the reason that blocking the CD47 'don't eat me' signal works to kill cancer is that leukemias, lymphomas and many solid tumors also display a calreticulin 'eat me' signal," said Irving Weissman, director of the Stanford Institute for Stem Cell Biology and Regenerative Medicine.
The rheumatoid arthritis shared epitope triggers innate immune signaling via cell surface calreticulin.
An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer.
Calreticulin exposure dictates the immunogenicity of cancer cell death.