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The fibrinous exudate included occasional eosinophils and was accompanied by interstitial neutrophils, a combination of findings that overlaps with so-called acute fibrinous and organizing pneumonia.
5,6) Other histologic patterns encountered in a clinical setting of ALI/ARDS include acute eosinophilic pneumonia (AEP) and the more recently described acute fibrinous and organizing pneumonia (AFOP).
When airspace organization is accompanied by nodular aggregations of fibrin in the alveolar spaces (but no hyaline membranes), the term acute fibrinous and organizing pneumonia is appropriate, as long as it is recognized that this diagnosis as an idiopathic condition has a guarded prognosis if the patient requires mechanical ventilation around the time of biopsy.