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The technique uses a zinc finger nuclease, a protein that can break up pieces of DNA, to effectively inactivate the receptor gene.
The new technique employs zinc finger nuclease (ZFN) proteins, which can bind and cut DNA at precisely defined locations in the genome.
With molecular editors called zinc finger nucleases, scientists correct a mutation in mice that leads to hemophilia (SN: 7/30/11 p.
Working with newborn mice, researchers led by Katherine High at the Children's Hospital of Philadelphia found that molecular editors called zinc finger nucleases can correct a genetic mutation that leads to the blood-clotting disorder hemophilia.
For the study, the researchers created a customized enzyme called a zinc finger nuclease (ZFN) to change single genes in tobacco plant cells.
Nasdaq: SGMO) announced the presentation of new data demonstrating the ability to permanently correct a disease gene in an adult mouse model of hemophilia B using systemic delivery of zinc finger nucleases (ZFNs) at the 53nd Annual Meeting of the American Society of Hematology (ASH).
com), is introducing a novel CHOZN GS-/- Zinc Finger Nuclease (ZFN)-modified Chinese Hamster Ovary (CHO) cell line.
Nasdaq: SGMO) announced the publication of a preclinical study demonstrating highly specific, functional correction of the alpha 1-antitrypsin (A1AT) gene defect in patient-derived induced pluripotent stem cells (iPSCs) using zinc finger nucleases (ZFNs).