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201404792) EMBO Molecular Medicine , scientists have deduced that the current outbreak of the fatal disease, caused by the Zaire Ebola virus or EBOV, was triggered by a young boy who got Ebola from a hollowed tree in their community.
Lytle cite that the highly virulent Zaire Ebola virus was used to determine the inactivation kinetics produced by exposure to specific doses of UVC from low-pressure mercury vapor (germicidal) lamps.
In the VSV-ZEBOV investigational vaccine, the gene for the outer protein of the Vesicular stomatitis virus has been replaced with a segment of the gene for the outer protein of the Zaire Ebola virus species.
Earlier preclinical studies were published in the medical journal The Lancet and demonstrated that when siRNA targeting the Ebola virus and delivered by Tekmira's LNP technology were used to treat previously infected non-human primates, the result was 100 percent protection from an otherwise lethal dose of Zaire Ebola virus (Geisbert et al.
The family Filoviridae contains 2 genera: Marburgvirus, which contains Marburg virus (MARV), and Ebolavirus, which contains 4 viruses: Zaire Ebola virus (ZEBOV), Sudan Ebola virus, Reston Ebola virus (REBOV), and Cote d'Ivoire Ebola virus, and 2 tentative species (Bundibugyo Ebola virus and Lloviu Ebola virus) (2,3).
Phase 1 clinical trial will evaluate safety, tolerability, and pharmacokinetics of drug to fight the lethal Zaire Ebola virus
The Zaire Ebola virus species (Ebola virus-Z), 1 of the 4 known species of Ebola virus, occurs in central Africa and kills 80% of infected persons within a few days (3,4).