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Samples in periodicals archive:
Higher scores on the Young Mania Rating Scale in the past month increased the risk of progression by 3%, which was statistically significant.
The efficacy of asenapine was studied using two scales; for manic symptoms the Young Mania Rating Scale (YMRS) and the Montgomery- Easberg Depression Rating Scale (MADRS) for depressive symptoms.
The program will use a variety of structured assessments, including the Beck Depression Inventory (BDI), the Montgomery-Asberg Depression Rating Scale (MADRS), the Young Mania Rating Scale (YMRS) and the Clinical Global Impression scale (CGI).
The application for the acute treatment of manic or mixed episodes associated with Bipolar I Disorder includes results from three positive placebo-controlled trials in over 1000 patients, two flexible dose studies and one fixed-flexible dose study using the change from baseline in the Young Mania Rating Scale (YMRS) total score as primary efficacy endpoint.
In 158 patients who were randomized to receive 3 weeks of double-blind treatment with the orally active dopamine D3-preferring D31 D2 receptor partial agonist, the mean improvement on the Young Mania Rating Scale (YMRS), based on a mixed-effects model of repeated measures, was significantly greater than the mean improvement in 151 patients who had been randomized to receive placebo, Anjana Bose, Ph.
For the primary endpoint, the Young Mania Rating Scale (YMRS), the data showed that patients with acute manic episodes treated with cariprazine experienced significant symptom improvement compared to placebo patients within the first week of treatment and at each subsequent time point studied.
[xx] The rating scales included the Young Mania Rating Scale (YMRS) which looked at speech rate and amount, appearance, motor activity/energy, sleep and language thought disorder including sexual interest, elevated mood and irritability/disruptive or aggressive behaviour.
Overall, patients in both groups showed statistically significant improvements in their scores on the Young Mania Rating Scale at the end of the study.