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They focus on physiological changes in liver function tests during normal pregnancy; liver disease not specific to pregnancy, such as viral hepatitis, gall stone and biliary disease, hepatic vein thrombosis, primary biliary cirrhosis, hepatic adenoma, Wilson disease
, and portal hypertension; liver disease unique to pregnancy, including hyperemesis gravidarum, intrahepatic cholestasis, preeclampsia-induced liver disease and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome, and the acute fatty liver; and transplantation.
Causes may be classified as: (a) viral (hepatitis A, B, and/or D; Epstein-Barr virus; and others); (b) drug- and toxin-induced (notably acetaminophen); (c) vascular ("shock liver," Budd-Chiari syndrome, and veno-occlusive disease); (d) metabolic [acute fatty liver of pregnancy, HELLP (hemolysis, increased liver enzymes, low platelets) syndrome, Reye syndrome, Wilson disease
(WD), and other inherited metabolic disorders]; and (e) diverse [sepsis, autoimmune hepatitis (AIH), and hepatic infiltrations] (1).
Sarah, who is from Riyadh, has, since the age of four, been suffering from Wilson disease
, a rare and inherited disorder that causes one's body to retain copper.
4) Other causes of Psychosis Psychotic symptoms can be induced by a large variety of conditions, including drug abuse, alcohol, medication, toxic poisoning, and vitamin deficiency, as well as diseases, such as brain tumours, Wilson disease
, thyroid dysfunctions, syphilis, lupus, AIDS, Creutzfeldt-Jakob disease (CJD), multiple sclerosis and epilepsy.
org/[Online 18 November 2002] ********** Chronic liver injury from diverse causes such as viruses, parasites, alcohol, hereditary metal overload, for example, Wilson disease
, and xenobiotics may give rise to a constellation of abnormalities such as fatty change, apoptosis, necrosis, cholestasis, inflammation, and fibrosis as well as nodular regeneration and cirrhosis.
Rosenfield N, Grand RJ, Watkins JB, et al: Cholelithiasis and Wilson disease
[7,8] Reversibility of hepatic fibrosis and cirrhosis has been reported in other liver diseases, such as autoimmune hepatitis, Wilson disease
, and bile duct disease.
Therapy Area Pipeline Report contains detailed information on the Wilson disease