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The patient was previously treated with vincristine and prednisone, followed by chemotherapy according to the R-CHOEP-14 protocol (3 cycles) (November 2003 through January 2004).
He also received doses of vincristine and prednisone without any effect.
David Main, INEX's President and CEO, said the current standard first- line treatment for the aggressive form of NHL is the CHOP chemotherapy combination, comprising the drugs cyclophosphamide, doxorubicin hydrochloride, vincristine and prednisone.
In another clinical study conducted at the same research center, 16 children with ALL refractory to regimens containing vincristine (an anticancer drug) and prednisone (a corticosteroid drug) were given VUMON along with vincristine and prednisone.
At the time the study was stopped, 322 patients who responded or had stable disease following induction cyclophosphamide, vincristine and prednisone (CVP) chemotherapy had been randomized to receive either Rituxan maintenance therapy or no further treatment.
The study was designed to evaluate Rituxan plus cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy compared with CHOP alone as a front-line therapy, followed by Rituxan maintenance therapy or observation.
Patients were randomized to receive six cycles of cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) or CHOP-like chemotherapy alone or in combination with six doses of Rituxan (375 mg/m2).