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What does VCR stand for?

VCR stands for Vincristine

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About the HALLMARQ Study Title: "A Phase 3, Multicenter, Randomized Study to Evaluate the Substitution of Marqibo (Vincrisitne Sulfate Liposomes Injection, VSLI) for Standard Vincristine Sulfate Injection (VSI) in the Induction, Intensification, and Maintenance Phases of Combination Chemotherapy in the Treatment of Subjects greater than or equal to 60 Years Old with Newly Diagnosed Acute Lymphoblastic Leukemia (ALL).
Introduction Vincristine is one of vinca alkaloid that is derived from madagascar perivinkle plant (Vincarosea) that binds to tubulin and inhibit its polymerization into microtubules, preventing spindle formation in dividing cells and causing arrest at metaphase [19,3].
The treatment of choice is chemotherapy, which usually includes cyclophosphamide, vincristine, and prednisone.
The committee will also review Ilex/Enzon's liposomal vincristine formulation Marqibo NDA (21-600) for relapsed aggressive non-Hodgkin's lymphoma and Ilex' Clolar (clofarabine) NDA (21-673) for pediatric patients (1-21 years) with refractory or relapsed acute leukemias on Dec 1.
The standard CHOP treatment (cyclophosphamide, doxorubicin hydrochloride [Adriamycin], vincristine [Oncovin], and prednisone) usually yields poor outcomes in patients who develop AIDS-related lymphoma, with complete remission rates reported to be only 40%-50% and a median survival of less than 12 months.