What does VOD stand for?

Etiology from most prevalent to least was as following: congenital heart diseases (27%), chronic thromboembolic pulmonary hypertension (24%), connective tissue diseases-scleroderma (14%), idiopathic PAH (8%), diastolic dysfunction (3%), pulmonary disease (3%), pulmonary veno-occlusive disease (2%), hepatopulmonary hypertension (1%), and HIV-infection associated PAH (1%).

Peak systolic blood flow improved in three (43%) of seven men with baseline hemodynamic impairment, and veno-occlusive disease resolved in three (18%) of 17 individuals.

When bone-marrow transplants are unsuccessful, the liver often fails due to the effects of the drugs, cancer, infection or a complication known as veno-occlusive disease that blocks blood flow in the liver.

About VOD Veno-occlusive disease is a potentially life-threatening condition, which typically occurs as an important complication of stem cell transplantation.

NASDAQ: GENT) today announced top-line results from a historically controlled, multicenter, open label, Phase III trial designed to evaluate the safety and efficacy of 25 mg/kg/day of Defibrotide for the treatment of severe veno-occlusive disease (sVOD) in hematopoietic stem cell transplant (SCT) patients.

The product is being distributed to healthcare professionals for the treatment and prevention of veno-occlusive disease (VOD) post SCT.

Notwithstanding our current financial position, Gentium continues to move forward with the development of Defibrotide to treat and prevent veno-occlusive disease (VOD), a disease for which there is no other treatment option," stated Dr.

The Phase 2/3 European pediatric prevention trial is a multi-center, open label, randomized clinical trial to evaluate the prophylactic use of Defibrotide in pediatric patients undergoing stem cell transplantation who are at high risk for hepatic Veno-Occlusive Disease (VOD).