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Several studies show that tigecycline is as active as the combination of vancomycin and aztreonam in skin and soft tissue infections (where it is necessary to cover the presence of MRSA and Gram-negative pathogens).
The results of this 702 patient study demonstrated that ceftaroline monotherapy achieved its primary endpoint of non-inferiority versus the combination of vancomycin and aztreonam in the treatment of complicated skin and skin structure infections (cSSSI).
The authors concluded that tigecycline is not inferior to vancomycin and aztreonam for the treatment of cSSSI.