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Elevated urinary free cortisol in patients with dementia.
Subsequently, urinary free cortisol (UFC) (normal range: <110[micro]g), urinary normetanephrine (normal range: 88-444 [micro]g/day) and urinary metanephrine (normal range: 52-341 [micro]g/day) were measured and the 1 mg overnight dexamethasone suppression test (DST) was performed.
SOM230 reduced urinary free cortisol (UFC) levels in majority of patients; 26% of patients randomized to SOM230 900ug achieved normal UFC levels With reduced UFC levels, clinical symptoms improved including lower blood pressure, total cholesterol and weight loss Cushing's disease is caused by a pituitary tumor that triggers excess cortisol; can lead to severe cardiovascular, metabolic problems and death This pivotal trial is the largest study of a medical therapy in Cushing's disease and will be basis for first regulatory filing planned by year end EAST HANOVER, N.
The 2 recommended screening tests for Cushing syndrome are the overnight dexamethasone suppression test and the measurement of 24-hour urinary free cortisol excretion.
24-Hour Urinary Free Cortisol Level This is the most specific test for diagnosing Cushing's syndrome.
Low-dose dexamethasone suppression test (DST), 24-h urinary free cortisol (UFC) levels, highdose DST, corticotropin-releasing hormone (CRH) test and imaging modalities are among the current diagnostic approaches (4).
Therefore, patients receiving a large dose of a potent topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests.
In agreement with the results of Lloyd (1) published in 1952, later investigators claimed a stimulatory influence of water diuresis on urinary free Cortisol (UFC) in healthy individuals (2-5).