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In the developing kidney, GATA3 is expressed in the ureteric bud along the branching process that gives rise to the collecting system of the definitive kidney, as well as in the glomerular mesangium and adjacent endocapillary cells.
The kidney derives from the nephric ridge of the intermediate mesoderm where the pro-nephric duct elongates to form the Wolffian duct, which in turn gives rise to the ureteric bud and sets the stage for condensation of metanephric mesenchyme and mesynchemal-to-epithelial cell transition.
The most probable cause of crossed renal ectopy was abnormal development of the ureteric bud during the fourth to eighth weeks of gestation.
GDNF stimulates ureteric bud outgrowth and enhances survival of ureteric bud cells in vitro.