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The regulated modification and degradation of cellular proteins by the ubiquitin-proteasome system are critical for modulation of many essential cellular processes including cell death.
Their paper, Chloroplast Biogenesis is Regulated by Direct Action of the Ubiquitin-Proteasome System, is due to be published in the journal Science on November 2.
Parkin is a broad neuroprotective agent that acts against a wide range of toxic insults, including those that are not part of the ubiquitin-proteasome system.
Following the Nobel-awarded discovery of the ubiquitin-proteasome system in 2004, IBRB's Molecular and Cellular Ageing Programme is one of the world's most significant research groups working in the Proteasome and Human Ageing field with a number of globally-recognised publications on this subject.
Neuronal cell adhesion molecules "are critical in the development of the nervous system, contributing to axonal guidance, synaptic formation and plasticity, and neuronal-glial interactions," the researchers explained, while the ubiquitin-proteasome system "operates pre- and post-synaptic compartments, regulating synaptic attributes, including transmitter release, synaptic vesicle recycling in pre-synaptic terminals, and dynamic changes in dendritic spines and the post-synaptic density.
Gupta, the Ubiquitin-Proteasome system controls basic cellular processes such as cell division, cell signalling and gene regulation.
Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions.
His career has focused on investigating the cellular machinery that mediates protein degradation by the Ubiquitin-Proteasome System (UPS), and how this machinery regulates cell division.