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The accumulation of pro alpha 1(I) and pro alpha 2(I) mRNAs and the transcriptional activity of these genes were determined in human skin fibroblasts in order to investigate site(s) of regulation of type I collagen production by human EGF in the absence and presence of L-ascorbic acid 2-phosphate (Asc 2-P), a long-acting vitamin C derivative.
The patent discloses improved methods for estimating bone resorption by measuring fragments of type I collagen containing certain age-modified (isomerised) peptide sequences.
Finally, cells on type I collagen resemble cells in a "wounded" liver, for example the liver of a hepatitis patient or a liver repeatedly exposed to alcohol.
Initially, FibroGen is offering two of the 20 known human collagens through its web site: type I collagen and type III collagen.
HealthWire)--May 12, 1999-- Licensing Obtained from the Washington Research Foundation Cohesion Technologies (NASDAQ NM: CSON) today announced that the Company has demonstrated feasibility with its recombinant collagen technologies, having generated a thermally stable human Type I collagen and gelatin in yeast in a novel and proprietary form.
1988-509161, includes 11 claims directed to assay methods, antibodies, and test kits for measuring N-telopeptides of type I collagen (NTx) as an indication of human bone resorption.
This in vitro study reported a positive reaction of an N-telopeptides assay with skin collagen, indicating that the assay reacts generally with other type I collagen rather than being specific for bone collagen.