When tumor suppressor genes are lost, it's common for several nearby genes-which play no role in cancer development-to be lost as well," explained the study's co-senior author William Hahn, MD, PhD, of Dana-Farber.
What does p53 stand for?
p53 stands for Tumor Suppressor Gene
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Samples in periodicals archive:
This approach has shown promise, for example, in our INGN 401 program, in which the FUS-1 tumor suppressor gene is administered intravenously to patients with metastatic lung cancers.
Nairn has identified a Xiphophorus gene correlating to the p16 tumor suppressor gene in humans that seems to be associated with susceptibility to developing melanoma upon exposure to UV light.
We believe that they support the vast potential of Canji's tumor suppressor gene therapy.
His research on tumor suppressor genes has not only advanced our understanding of cancer, but it also has provided valuable insight in the role that hereditary predisposition plays into developing cancer," said Dr.
Working with Stanford colleagues Xu Li and Uta Francke, they have now located the human version of tsg101 on a region of chromosome 11 suspected of containing a tumor suppressor gene involved in breast and other cancers.
The company's therapeutic approach is to replace lost tumor suppressor gene functions in cancer cells, thereby inhibiting cancerous growth or inducing these tumor cells to undergo programmed cell death ("apoptosis").
] the first time that two functional tumor suppressor genes have been used in a nanoparticle treatment [?