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When tumor suppressor genes are lost, it's common for several nearby genes-which play no role in cancer development-to be lost as well," explained the study's co-senior author William Hahn, MD, PhD, of Dana-Farber.
This approach has shown promise, for example, in our INGN 401 program, in which the FUS-1 tumor suppressor gene is administered intravenously to patients with metastatic lung cancers.
Nairn has identified a Xiphophorus gene correlating to the p16 tumor suppressor gene in humans that seems to be associated with susceptibility to developing melanoma upon exposure to UV light.
We believe that they support the vast potential of Canji's tumor suppressor gene therapy.
His research on tumor suppressor genes has not only advanced our understanding of cancer, but it also has provided valuable insight in the role that hereditary predisposition plays into developing cancer," said Dr.
Scott Powers, Director of the Human Cancer Genome Center at CSHL, used a highly efficient genome-sequencing technique to scan the genomes of liver cancers from more than 100 patients to compile a list of deletions of chromosomal regions, which were hypothesized to be the location of most of the missing tumor suppressor genes.
Working with Stanford colleagues Xu Li and Uta Francke, they have now located the human version of tsg101 on a region of chromosome 11 suspected of containing a tumor suppressor gene involved in breast and other cancers.
The company's therapeutic approach is to replace lost tumor suppressor gene functions in cancer cells, thereby inhibiting cancerous growth or inducing these tumor cells to undergo programmed cell death ("apoptosis").