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The PRIDE trial looked at time to treatment failure in 444 schizophrenia patients over 15 months--226 were treated with IM paliperidone (Invega Sustenna) and 218 were treated with one of seven oral antipsychotics (aripiprazole, haloperidol, olanzapine, paliperidone, perphenazine, quetiapine, or risperidone).
Compared with people infected only with HIV, those infected with HIV plus HCV had a significantly shorter time to treatment failure after starting antiretroviral therapy.
The topline primary endpoint results for the trial indicate that CellCept[R] was highly statistically significantly superior to azathioprine in delaying the time to treatment failure.
Approval of efavirenz was based on 2 clinical trials in which the response was measured as time to treatment failure.
Study met primary endpoint of 50% prolongation of time to treatment failure over that expected for standard RCHOP alone; estimated 73% 5-year overall survival with ZEVALIN
PRIDE assessed as its primary endpoint time to treatment failure, which is a subset of relapse.
The primary endpoint was time to treatment failure (TTTF), defined as disease that progresses within six months of the last rituximab treatment, disease that doesn't respond to therapy, need for alternative therapy, or inability to complete the treatment protocol.
El-Nashar reported that there were no significant differences in the time to treatment failure between the two groups, with a 3-year cumulative failure rate of 9% in the RFA group, compared with 12% in the TBA group.