What does TTCW stand for?

Secondary endpoints include time to clinical worsening, World Health Organization (WHO) Functional Class and Borg Dyspnea Index.

Secondary objectives were to evaluate the effects of ambrisentan on other clinical measures of PH, including the number of patients still alive at specified time points and time to clinical worsening, which was defined as the time from initiation of ambrisentan to the first occurrence of death, lung transplantation, hospitalization for PH, atrial septostomy, a change to chronic prostanoid therapy or sildenafil due to protocol-defined worsening criteria or study withdrawal due to addition of other PH medications.

Secondary endpoints include time to clinical worsening of PAH during the 12-week placebo-controlled treatment period and change from baseline after 12 weeks in Borg dyspnea index (BDI, a measure of breathing ability), WHO functional class, SF-36[R] Health Survey physical functioning scale and various hemodynamic measures.

Time to clinical worsening did not reach statistical significance likely due to the relatively low incidence of clinical worsening events observed in the trial.

will present "Ambrisentan Improves Exercise Capacity and Time to Clinical Worsening in Patients with Pulmonary Arterial Hypertension: Results of the ARIES-2 Study.

Treatment with Tracleer also was associated with a significant delay in the time to clinical worsening as defined as death, hospitalization, worsening PAH or initiation of intravenous therapy (p=0.