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The technique is based on the assumption that when during the tidal breathing the airway is suddenly occluded, there is a pressure change in the mouth, which equals the resistive pressure drop across the airways.
Normal subjects increase their tidal breathing up to about 50-60% of their VC, and then accomplish further increases in ventilation by increasing the breathing frequency.
Unit Dose Budesonide (UDB): A New Submicron Dispersion of Nebulizable Budesonide Studied in 360 Children 12 Months to 8 Years Old with Mild to Moderate Persistent Asthma--The CASTLE I Study" -- "A Novel Budesonide Formulation for Nebulization Significantly Improves the Amount of Drug Emitted over One Minute in a Simulated Pediatric Tidal Breathing Model" -- "A Novel Aqueous Dispersion of Budesonide Significantly Improves the Aerodynamic Particle Sizing Distribution of Budesonide from Various Jet Nebulizers Compared to a Marketed Budesonide Suspension" -- "Comparative Pharmacodynamics and Pharmacokinetics of MAP0005 (Formoterol-Budesonide Combination Particles Delivered via the Tempo(R) Inhaler) in Mild to Moderate Asthmatics"
2]O/ year) (Niewohner et al 1975, Turner et al 1968), resulting in an increase in closing capacity, ie, the lung volume at which there is closure of the small airways in the gravity dependent lung regions during tidal breathing (Leblanc et al 1970).
The turbine's flow trigger algorithm allows tidal breathing prior to a patient's expiratory effort.
Research into the damage caused by mechanical ventilation (ventilator-induced lung injury) has been focused largely on the primacy of repeated stresses and strains encountered by the lung parenchyma and unsupported small airways during tidal breathing.
It is but a short step from the construction of such "quasi-static" curves inscribed during very low flow to the analysis of the pressure-time contours during passive tidal breathing at normal rates of "square wave" (constant) flow.
It is but a short step from the construction of such "quasistatic" curves inscribed during very low flow to the analysis of the pressure-time contours during passive tidal breathing at normal rates of "square wave" (constant) flow.