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Before gene defects in the thyroid hormone receptor (TR) were recognized, patients with RTH were classified on clinical grounds alone into either generalized resistance (GRTH), pituitary resistance (PRTH) or combined.
PBDE exposure can also affect binding to thyroid hormone receptors and transport proteins.
CHICAGO -- A new generation of oral selective thyroid hormone receptor agonists is showing promise for the treatment of dyslipidemia, obesity, and metabolic syndrome.
Thyroid anti-microsomal antibodies (also known as thyroid peroxidase antibodies or TPO antibodies) are increased in most (80-90%) patients with Graves disease, and thyroid hormone receptor antibodies (TRAbs) are increased in ~80% or more of patients (25, 28).
Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs" J.
A detailed study now provides one of the most insightful assessments to date of how environmentally relevant levels of PBDEs may impair brain development by interfering with thyroid hormone receptor (TR)-mediated transcription [EHP 119(2):168-175; Ibhazehiebo et al.
RTH is mostly caused by mutations in the thyroid hormone receptor (TR) [beta] gene (6).
In addition to the first generation compound entering the clinic, the companies continue to collaborate on the development of second-generation compounds which may expand the possible indications attributed to this class of novel thyroid hormone receptor agonists.