What does THBS stand for?

In the NG-treated platelets, there were increase in the levels of growth factor receptor-bound protein 2 (Grb2), thrombospondin 1, tubulin alpha 6 and decrease in the levels of thioredoxin, Cu-Zn superoxide dismutase, DJ-1 protein, peroxiredoxin 3, thioredoxin-like protein 2, ribonuclease inhibitor, potassium channel subfamily V member 2, myosin regulatory light chain 9 and laminin receptor 1.

They contain RNA, mitochondria, a canalicular system, and several different types of granules; lysosomes, dense granules (containing ADP, ATP, serotonin, histamine, and calcium), and alpha granules (containing fibrinogen, factor V, vitronectin, thrombospondin and von Willebrand factor), the contents of which are released upon activation of the platelet.

Autocrine thrombospondin partially mediates TGF-beta1- induced proliferation of vascular smooth muscle cells.

[53-57] Link protein, as discussed above, is required to stabilize the PG aggregates in the cartilage matrix, fibromodulin interacts with various matrix components and controls collagen fibril formation, osteopontin sequesters calcium and promotes tissue calcification, and thrombospondin plays a role in cell attachment.

3,4) This protease has recently been identified as a new member of the zinc metalloproteases, ADAMTS13 (A Disintegrin And Metalloprotease with ThromboSpondin Type 1 motifs).

Brittain and her colleagues found that the integrin molecules could bind a cell to a vessel wall by attaching to thrombospondin there.

She is a postdoctoral fellow at the University of Maryland School of Medicine, pursuing studies of thrombospondin in human microvascular endothelial cells.

These polymorphisms include mutations of factor XII, tissue plasminogen activator, plasminogen activator inhibitor 1, thrombospondin, angiotensin-converting enzyme, and insulin receptor substrate 1.