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Samples in periodicals archive:
High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy.
Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation.
Anderson Cancer Center have shown that low levels of thioredoxin reductase 1 (TRX-1), an antioxidant, which is associated with resistance to cisplatin - a common first-line treatment of lung cancer - leads to high levels of reactive oxygen species (ROS) in lung cancer cells and enhanced sensitivity to elesclomol.