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One study demonstrates that SL-401 potently inhibits the growth of several Hodgkin's lymphoma (HL) cell lines, and has activity against mantle cell lymphoma (MCL), a non-Hodgkin's lymphoma, as well as T-cell acute lymphoblastic leukemia (T-ALL) cell lines.
Trisomy 4 as the sole cytogenetic abnormality in a patient with T-cell acute lymphoblastic leukemia.
On the other hand, TCRG gene rearrangements are known for their high stability from diagnosis to relapse in T-cell acute lymphoblastic leukemia because they are mostly end-stage rearrangements (34).
In November 2006, the EMEA granted orphan drug designation to Fodosine(TM) for the treatment of T-cell acute lymphoblastic leukemia (ALL).
In this multicenter Phase II clinical trial, 50 patients with relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) were treated.
European Medicines Agency (EMEA) Grants Orphan Medicinal Product Designation to BioCryst's Lead Oncology Candidate, Fodosine(TM), for Treatment of T-Cell Acute Lymphoblastic Leukemia (T-Cell ALL) BIRMINGHAM, Ala.
15 /PRNewswire/ -- Researchers' discovery of clues to the cause of T-cell acute lymphoblastic leukemia (T-ALL) - a form of pediatric cancer that has a very poor prognosis - could lead to the development of new targeted therapies for this extremely difficult disease.
New option for children and adults with treatment resistant T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) PHILADELPHIA, Oct.