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Chromogranin, synaptophysin, and parathyroid hormone will be reactive by immunohistochemistry.
Several immune markers may be detected which include neuron-specific enolase (NSE), vimentin, synaptophysin and S-100.
Pancreatoblastomas also often contain a neuroendocrine component that stains with antibodies against synaptophysin and chromogranin, adding to the confusion.
The patient was diagnosed as GN after observing positivity for chromogranin and synaptophysin in ganglion cells and for S-100 in Schwann cells in immunohistochemical evaluation.
Western blot analysis of selected proteins in the brain such as glial fibrillary acidic protein (GFAP), synaptophysin and neurofilament (NF) at increasing PMI and quantitation (normalized against tubulin) showed no significant change in GFAP signal in FC, CB and CD, while SN revealed a significant increase in GFAP signal (Fig.
This virus, through a receptor-mediated process, selectively targets neuroendocrine tumor cells that express at least one of the following three biomarkers: synaptophysin, CD56, or chromogranin A.
Immuno perox idase studies were performed on core biopsies from the case and showed positive staining with chromogranin, synaptophysin, keratin, and thyroid trans cription factor.
KEY WORDS: adrenocortical carcinoma, Cushing's syndrome, hirsutism, pheochromocytoma, synaptophysin, virilization