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HEPLISAV merges hepatitis B surface antigen with a Toll-like Receptor 9 agonist to boost the immune response.
An estimated 90%-95% of healthy adults aged 40 years and younger achieve a protective antibody titer (defined as anti-hepatitis B surface antigen concentrations of 10 mIU/mL or greater) after receiving the three-dose series (MMWR2011;60[RR07]:l-45).
ABBOTT PARK, Illinois, November 9, 2011 /PRNewswire/ -- - New Highly Sensitive Hepatitis Test Detects Mutant Virus Strains Abbott announced it has received CE Marking (Conformite Europeenne) in the European Union to market a new, highly sensitive diagnostic test for detection of hepatitis B surface antigen (HBsAg).
Since shortly after its discovery as the "Australia antigen" (1), hepatitis B surface antigen (HBsAg) has been the principal target for laboratory testing to identify active infection by HBV.
A collection of tumors induced by inoculation of specific strains of MDV, ALV, and REV, alone or in combination, were tested for quantification of MDV DNA by real-time polymerase chain reaction, expression of the MDV oncogene Meq, expression of several cell markers associated with transformation (CD30, Marek's disease-associated surface antigen, and p53), and level of DNA methylation in the tumor cells.
Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels.
The researchers also tested blood from 18 patients and 54 controls for hepatitis B surface antigen, an indicator of hepatitis B infection.
Type A viruses are divided into subtypes based on two surface antigens nuraminidase (N) and hemagglutinin (H); the B virus is not categorized by subtypes.