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The primary objectives of the study were to evaluate the safety and tolerability of escalating doses of JVS-100, a non-viral gene therapy expressing stromal cell-derived factor 1 (SDF-1), delivered via direct intramuscular injection to patients with CLI.
Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression.
Time course of myocardial stromal cell-derived factor 1 expression and beneficial effects of intravenously administered bone marrow stem cells in rats with experimental myocardial infarction.
JVS-100 is a non-viral plasmid that expresses stromal cell-derived factor 1 (SDF-1), which has been shown to activate natural stem cell based repair pathways and improve cardiac function in pre-clinical and Phase I clinical studies," states Dr.
Stromal cell-derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G0/G1 transition in [CD34.
JVS-100, the Company's lead product, is a non-viral gene therapy that encodes stromal cell-derived factor 1 (SDF-1).
Stromal cell-derived factor 1a activates LIM kinase 1 and induces cofilin phosphorylation for T-cell chemotaxis.
JVS-100, the Company's lead product, encodes Stromal cell-Derived Factor 1 (SDF-1).