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6,7) MUC4 expression has been reported in many carcinomas, including squamous cell carcinoma of the upper aerodigestive tract and carcinomas of pancreatic, salivary, breast, lung, gastric, colon, biliary tract, and ovarian origin.
Squamous cell carcinoma of the upper aerodigestive tract is associated with a higher rate of metastasis to the regional lymph nodes than is squamous cell carcinoma of the skin.