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Spindle cell squamous cell carcinoma (SCSCC) is a squamous cell carcinoma (SCC) with a biphasic appearance, yielding a spindle cell transformation.
64) To differentiate spindle cell squamous cell carcinoma from other spindle cell neoplasms, such as atypical fibroxanthoma, spindle cell melanoma, leiomyosarcoma, and others, investigators demonstrated that spindle cell squamous cell carcinoma expressed p63 strongly and diffusely, whereas most controls were negative or displayed weaker and more focal staining.
 Other lesions that can mimic atypical fibroxanthoma are spindle cell squamous cell carcinoma and desmoplastic or spindle cell melanoma.