What does SKY stand for?

Characterization of complex chromosomal abnormalities in uveal melanoma by fluorescence in situ hybridization, spectral karyotyping, and comparative genomic hybridization.

Examples of topics covered include the plasma cell labeling index, multicolor spectral karyotyping, detection of chromosome 13 deletions by fluorescent in situ hybridization, identification and of clonotypic IgH VDJ sequences, real-time polymerase chain reaction of immunoglobulin rearrangements for quantitative evaluation of minimal residual disease, determination of telomerase activity and telomere length, clonality detection of the expanded t-cell populations in patients with multiple myeloma, and use of DNA micrrarray data.

Spectral karyotyping (SKY) was a key diagnostic tool in eight papers presented at the recent annual meeting of the American Association for Cancer Research (AACR) in Philadelphia, PA.

The Company also operates a Cytogenetics Services Laboratory (CLIA approved) and a Genomic Services Laboratory which both perform karyotyping and chromosome analysis by G-banding, Spectral Karyotyping (SKY), FISH and comparative genomic hybridization (CGH) for the clinical and research communities.