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[FIGURE 2 OMITTED] Panel A shows the outcomes of sister chromatid exchange (SCE) involving a ring chromosome.
A study showed that people with exposure to environmental pollutants such as PAHs were associated with significant increases in carcinogen-DNA adducts (PAHDNA and aromatic adducts), in sister chromatid exchange including high-frequency cells, and in chromosomal aberrations as well as a doubling in the frequency of ras oncogene overexpression (Perera et al.
For example, morphine was shown to enhance the frequency of UV-induced sister chromatid exchanges (Shafer et al.
Sister chromatid exchange analysis For sister chromatid exchange analysis, bromodeoxyuridine (BrdU, 10 mg/ml) was added at the beginning of the culture.
3-fold increase in the mean number of sister chromatid exchanges (the number of crossover events in a chromosome pair), from 6.
Chromosome aberrations, Sister chromatid exchanges, unscheduled DNA synthesis and morphological neoplastic transformation in Syrian hamster embryo cells.
Teniposide also caused a dose-related increase in sister chromatid exchanges in Chinese hamster ovary cells and it has been shown to be embryotoxic and teratogenic in rats receiving teniposide during organogenesis.
Increased sister chromatid exchange (SCE) frequencies in lymphocytes from traffic policemen exposed to automobile exhaust pollution.