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Genetic links of the type have been reported for PUUV infections in Finland (11) and for Sin Nombre virus infection during the outbreak in the Four Corners area of the United States (4,12), but perfect sequence match was not observed.
Deer mice are the only ones that have really been proven to transmit the particular virus, the sin nombre virus that we have.
Recent examples include the 2002 outbreak of Sars virus, which killed hundreds of people, the Ebola virus - linked to fruit bats - which has caused several disease outbreaks since 1976, and the Sin Nombre virus, linked to the deer mouse, which caused deaths in the US in 1993.
The viruses known to cause HPS on the North American continent are Bayou virus, Black Creek Canal virus (BCCV), Choclo virus (CHOV), New York virus, and Sin Nombre virus (SNV) (3-7).
In binding assays, antibody to all known hantaviruses indigenous to the Americas cross-react with the N protein of Sin Nombre virus (10).
In the United States, most HPS cases are likely caused by Sin Nombre virus (6), the virus responsible for the initially identified HPS cases.
The respiratory form of the disease was described in June 1993 during an epidemic of severe respiratory disease caused by Sin Nombre virus in the United States (3).
These samples were tested by IgM capture with inactivated Sin Nombre virus antigens and by indirect ELISA with recombinant antigens to detect IgG antibodies to Sin Nombre virus (10).