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Analysis of DNA samples from these individuals suggests the inheritance of a common defect in a single gene located on the short arm of chromosome 11 (11p; Smith et al.
The presence of a specific marker (a restriction-fragment-linked polymorphism, or RFLP) on the short arm of chromosome 11 increases 100-fold the likelihood of affective disease in a member of this family, Kidd reports.
White reports, for example, that recombination in the short arm of chromosome 11 is about three times as frequent in males as in females, but recombination in chromosome 13 is more frequent inf emales than in males.