What does SAM stand for?

A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder.

There are three principle DNA methyltransferases, Dnmt 1, Dnmt 3a, and Dnmt 3b that catalyze the transfer of a methyl moiety from the cofactor S-adenosyl-L-methionine (SAM).

A report on the dietary supplement S-adenosyl-L-methionine (SAM-e), titled, "S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis and Liver Disease," was recently released.

According to the report, the team's key findings include evidence that SAMe: -- Is as effective as prescription antidepressants in treating depression (47 studies reviewed) -- Fights osteoarthritis pain as well as prescription and over-the-counter joint pain relievers called non-steroidal anti-inflammatory drugs (NSAIDS) (14 studies reviewed) -- May help some liver conditions (more than 40 studies reviewed) Also according to the report's summary, the objective of the report "was to conduct a search of the published literature on the use of S-adenosyl-L-methionine (SAMe) for the treatment of osteoarthritis, depression and liver disease.

According to the Evidence Report's summary, the team's key findings include evidence that SAM-e: -- Is as effective as prescription antidepressants -- Fights osteoarthritis pain as well as non-steroidal anti-inflammatory drugs (NSAIDS) -- Helps some liver conditions Also according to the summary, the objective of the Evidence Report "was to conduct a search of the published literature on the use of S-adenosyl-L-methionine (SAM-e) for the treatment of osteoarthritis, depression and liver disease.